Endocrine Abstracts

Introduction: The risk of pituitary apoplexy (PApopl) is up to 9.5%. In 80% of cases, it is the first manifestation of the disease.Material and methods: The study included 94 PApopl from 1 day up to 9 years. Conservative treatment was performed in 37 cases, and 59 were operated on including 14 giant posthemorrhagic cysts. The probability of resorption – it is possible in 85%, instead of cysts (the probability of resorption of ~ 15%). After 3 months,...

Objective: Prospective study of cabergoline effect in newly diagnosed patients with giant invasive prolactinomas.Patients and methods: The study group included 121 patients with giant prolactinomas (tumors larger than 40 mm in size); among them 49 patients had tumors larger than 60 mm in size. 91 male and 30 female aged 16–67 years (median 37) were treated with 0.5–3.5 mg/week (mean 1.5 mg) cabergoline. The treatment period was 6–120 month...

Suprasellar craniopharyngiomas (CF) are characterised by a high incidence of involvement of the third ventricle, which determines the risk of hypothalamic obesity (HO). There are no unified diagnostic criteria for HO and its effective treatment. The assessment of pre- and postoperative hypothalamic damage is necessary for the choice of surgical strategy and early therapeutic intervention.Objective: To estimate the incidence and extent of weight gain in a...

Reset osmostat syndrome (ROS) is characterized by a change of normal plasma osmolality level (decrease or increase), which leads to chronic dysnatremia (hypo- or hypernatremia). We have described a Clinical case of ROS and chronic hyponatremia in a patient with chordoid glioma of the III ventricle. It is known that the patient had previously been diagnosed with hyponatremia (131-134 mmol/l). She has not hypothyroidism and hypocorticism. There is normal filtration function of t...

Objective: To study the clinical, diagnostic and morphological characteristics and treatment outcomes of TSH-secreting pituitary tumors.Patients and methods: The study included 21 patients with pituitary adenoma and a normal or elevated TSH level and elevated fT4 and fT3 levels who were operated on at the Neurosurgical Institute in the period between 2002 and 2015. Before surgery, in the early postoperative period, and 6 months afte...

Objective: To analyze the remission factors of surgical treatment of acromegaly Methods: A retrospective study involving 227 patients with acromegaly: 143 (63%) women and 84 (37%) men were operated via trassphenoidal endoscopic approach for pituitary adenoma removal between the periods of 2018-2021. The average age was 45 years [36.00, 56.00]. 118 patients had 6 months follow-up period (3-40 months). The IGF-1 index used for the evaluation, which was cal...

The tumors of the thalamic-hypothalamic-pituitary system (diencephalon region, DR) include a fairly large group. These are pituitary adenomas, craniopharyngiomas (CP), pineal tumors, gliomas, meningiomas, and others. Tumors differ in the location, histological structure, and manifestations of the clinical picture with the corresponding hormonal changes, approaches and methods in treatment. Psychopathological symptoms are revealed in the symptoms of lesion of the DR in addition...